What is your end goal? There are a lot of different ways to install Wine for different purposes.
If it’s just to run a arbitrary binary, I use Heroic and add it as a non-Epic/Amazon game. Different Wine/Proton versions can be downloaded in the settings.
You can also add them to Steam as non-steam game and enable compatibility mode in the settings.


I’ve been using Mint+Home Manager on my main desktop and NixOS on other devices.