

Yes, I’m sure there are multiple professional software solutions that are expensive but can do it. Reconfiguring the equipment is much cheaper.
Even basic stuff like teleconferencing software can do it, like do y that when Zoom is playing audio it doesn’t pick it back up through a desk mic, unless the feedback is really bad.
If Minix counts, I got it running on a 286 some years ago. I don’t remember how much RAM it had, but it was very little.